Isolate a single vm to a host?

I have an interesting problem.  I need to take a single vm in a large cluster be the only vm on 1 of the hosts.  I know I can create a vm group with every other vm and a host group with every other host and restrict the movement by DRS, but that requires a lot of maintenance. Especially with frequent vm creation, like we have.

Does anyone have ideas on how else to solve this conundrum?

Thank you